The alteration of sex and non-sex hormones and distribution features of blood ABO system groups in the blood of the women with uterine tumors in Adjara population.

Author: Nanuli Kotrikadze
Co-authors: I. Nakashidze, L. Ramishvili
Keywords: Uterine tumors, hormones
Annotation:

The aim of the investigation was to study the hormonal status (sex hormones: progesterone (P), estradiol (E), testosterone (T) and non-sex gonadotropic hormones - luteinizing hormone (LH) and follicle-stimulating hormone (FSH)) of women with benign and malignant tumors of uterus in the reproductive, menopause and postmenopause periods, in Adjara population. Also the distribution features of the blood ABO system phenotype groups and their link to the development of uterine tumors have been studied. The determination of hormones was made by the enzymatic analysis method (ELAIZA), provided by proper ELAIZA kits. For the study of blood ABO system antigens, internationally recognized immunoserology methods were used. Investigations revealed the increased level of E and T on the background of the reduced P in the blood of the women with benign and malignant uterine tumors, in the reproductive, menopause and postmenopause period. As for gonadotropic hormones, the decreased levels of LH and FSH have also been detected. From the ABO system phenotype groups A(II) group had the highest frequency between the women with malignant tumor of uterus in the reproductive age. while O (I) phenotype group was the most frequent in case of menopause and postmenopause women. Revealed hormonal imbalance in women of the reproductive, menopause and postmenopause periods, creates good conditions for the proliferation of uterine tissues and hence causes the development of benign and malignant uterine tumors. The imbalance of the sex steroid and gonadotropic hormones in the blood of postmenopause women indicates on the genotoxic mechanism of cancer development on the background of age-related changes. A(II) group had the highest frequency between the reproductive age women with uterine malignant tumor. While O (I) group was the most frequent in case of menopause and postmenopause patients. Thus, in Adjara population, reproductive and menopause age women with AB (IV) group and postmenopause age women with B (III) have the lower risk of uterine cancer development.