Isolation as the inducer of oxidative stress

Author: George Burjanadze
Co-authors: George Burjanadze, Natalia Dachanidze
Keywords: Stress, Brain, Melatonin, Antioxidant system, Isolation, circadian rhythm
Annotation:

In our previous investigations it was shown, that isolation of individuals and simultaneously disruption of circadian rhythm represent strong factors, that induces changes in quantities of stress-hormones (serotonin, corticosterone) and melatonin and development of oxidative processes in rat brain. If consider, that melatonin is too strong endogenous antioxidant, it was important to clarify which exogenous factor stimulates oxidative processes in rat brain. Experiments were held on laboratory rats, that were divided into three groups: I. 30-day isolation of individuals under conditions of dark II. Keeping individuals in group under conditions of dark III. Control From the results is proved that activity of antioxidant system and quantitative increasing in lipid peroxidation (LPO) products in rat brain has place mainly in animals of group I (long-term isolation and dark). In conclusion it can be proved that isolation is strong stress-factor that could be an inducer and provoker of oxidative processes.